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Inform clients that: Tramadol Hydrochloride Extended-Release is for oral use only and will be swallowed whole. The capsule shouldn't be chewed, dissolved, crushed or split. Tramadol Hydrochloride Prolonged-Release may possibly lead to seizures and/or serotonin syndrome with concomitant use of serotonergic agents (together with SRIs, NRIs, and tript